In this talk, we will introduce a deep learning-based general numerical method coupled with small sample learning (SSL) for solving PDEs. To be more specific, we approximate the solution via a deep feedforward neural network, which is trained to satisfy the PDEs with the initial and boundary conditions. Then the proposed method is modeled to solve an optimization problem by minimizing a designed cost function, which involves the residual of the differential equations, the initial/boundary conditions and the residual of a handful of observations. With a few of sample data, the model can be rectified effectively and the predictive accuracy can be improved. The effectiveness of the proposed method is demonstrated by a wide range of benchmark problems in mathematical physics, including the classical Burgers equations, Schrodinger equations, Buckley-Leverett equation, Navier-Stokes equation, and Carburizing diffusion equations, which are applied in carburizing diffusion problems in material science. And the results validate that the proposed algorithm is effective, flexible and robust without relying on trial solutions.