Human brain stores tremendous amount of knowledge about this world, which is the foundation of language, thought, and reasoning. What’s the neural codes of knowledge representation? will present some work from my lab that addresses this issue using brain imaging experiments with healthy subjects, individuals with sensory deprivation (blind and deaf) or with brain damage. The findings point to a highly distributed system incorporating two forms of representations: sensory-derived and language-derived, spanning across multiple perceptual and language neural systems, each incorporating similar kinds of computations over different formats of information.