Alzheimer‘s disease (AD) is a chronic progressive disorder and is clinically characterized by a decline in cognition, behavior, and function. Increasing evidence suggests that astrocytes are the central player in the cellular phase of AD and is considered a potential therapeutic target for AD. Astroglial Ca2+ signaling underlies astroglial excitability hence Ca2+ dysregulation may be the proximal cause of AD. Modeling astrocyte Ca2+ dynamics is an essential step toward understanding their physiology and pathology in the AD. In this study, we developed several astrocyte Ca2+ dynamics models involved in AD to study AD’s pathology and inspire potential AD treatments from simulations.