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Neutron Workshop on Biological and Soft Matter Science

Neutron spin echo spectroscopy and its application to lipid membrane dynamics

Speaker

Michihiro Nagao , NIST Center for Neutron Research, USA

Time

13 May, 10:21 - 10:50

Abstract

Neutron spin echo spectroscopy (NSE) uses Larmor precession of neutrons in a magnetic field to resolve the smallest energy transfers among neutron scattering techniques. Typical timescales covered by NSE are sub ns to sub μ s while simultaneously covering length scales up to 10s of nm. Therefore, NSE is uniquely suited to measure the equilibrium dynamics of soft- and bio-materials such as polymers, proteins, colloids and membranes. Here, we introduce lipid bilayers and their dynamics as a typical soft matter system. Lipid molecules are the basic component of biological membranes, which serve as a permeable barrier of a cell. As cells deform, fuse, and divide, the bio-membranes require two contradicting characteristics: they must be rigid enough to accommodate the structure of the cell while soft enough to fulfill dynamic cell functions. The mechanical properties of membranes characterize these dynamics and determine the timescale of the membrane motions spanning from sub ns to seconds. NSE can contribute to our understanding of the nanometer and nanosecond scale motions by measuring the thermal fluctuations of membranes, such as undulation and thickness fluctuations. Recently our group developed a method to quantify bending and compressibility moduli and viscosity of membranes in single component lipid bilayers by combining experimental NSE data and proper theories. In this presentation, I will introduce the NSE technique, then focus on lipid membrane dynamics by showing our methodology and finally comment on future directions in NSE and membrane dynamics.