Wei Zhuang, State Key Lab of Structural Chemistry, Fujian Institute of Research on Structure of Matters
601 Pao Yue-Kong Library
Cytosol, a complex aqueous solution containing most of the intracellular water, is the site for many important bio-processes such as signal transduction as well as metabolism, in which water plays a critical role. However, our understanding about the state, structure, dynamics of water in cytosol, as well as how are these properties related to the biological functions remain elusive. Many evidences implicate that we can gain abundant information about the dynamics of cytosol water by simply looking at the water dynamics at the molecular interfaces in the in-vitro aqueous solutions mimicking the cytosol components (ions, small metabolite molecules and proteins).
We’ve therefore picked a series of typical ions, amphiphilic small molecules as well as proteins and carefully studies the water reorientational dynamics at their interfaces. Theoretical approaches including cyclic Markovian chain model are using to understand the apparently abnormal water behaviors therein. Based on these simulations, we attempt to address several important issues about the solute effect on interfacial water, including 1) ion specificity in their effects on water dynamics, 2) spatial range of solute effects, 3) micro-heterogeneity in the solutions, 4) coupling of water-protein dynamics and 5) coupling-slaving relationships of the dynamics of different components in the jammed intercellular spaces.