Molecular Structure and Ultrafast Energy Relaxation of Proteins at the Interface


Shuji Ye, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China


2019.04.18 13:00-14:00


Room 304, No. 5 Science Building


Many important processes of proteins including conformational transition of membrane proteins, folding and energy transfer, and the interaction between protein and materials occur at the surface and interface. The proteins embedded inside the cell membranes work as molecular machines to fulfill diverse biological and cellular functions. Their normal structures and functions play critical roles in the life-sustaining processes. Accurate characterization of the interfacial structure and dynamics of protein is therefore central to understand how proteins function. But it could only be utilized with a few very limited experimental methods in real environments. The talk will focus on recent progress of my group on the molecular structure and ultrafast energy relaxation of proteins at the lipid membrane interface investigated by surface-sensitive sum frequency generation vibrational spectroscopy, including the characterization of the intermediates during the folding and misfolding of proteins, gating action of the ion-channel protein, ultrafast conformational change and vibrational energy transfer of proteins.


Dr. Shuji Ye is a professor working at Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China(USTC). He received his bachelor degree at USTC in 1997, master degree at Guangzhou Institute of Chemistry, CAS in 2000, and Ph. D. degrees at the University of Tokyo in 2004. He worked as a postdoc at State University of New York at Buffalo from December 2004 to September 2006, and at University of Michigan at Ann Arbor from October 2006 to September 2009. After that, he took an associated professor position at USTC in 2009 and became a full professor in 2016. His research focuses on the physics and chemistry of complex molecular systems at the interface investigated by ultrafast and nonlinear spectroscopy. He has published over fifty first-author and corresponding-author peer-reviewed papers including those on J. Am. Chem. Soc., Angew. Chem. In. Ed., Nat. Commun., Sci. Adv., and so on. His research achievements were awarded with Second Class Award by China Association for Instrumental Analysis in 2014. He was awarded with Zhang Cunhao chemical dynamics award for young scientists by Chinese Chemical Society in 2017.