Chunhe Li,Shanghai Center for Mathematical Sciences, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University
Room 306, No. 5, Science Building
Cellular functions in biological systems are regulated by the underlying gene regulatory networks. How to investigate the global properties of gene networks is a challenging problem. In this talk, I will present some approaches we recently developed, i.e. the potential landscape and path framework, to study the stochastic dynamics of gene networks. The basins on the landscape characterize different cell states. The landscape topography in terms of barrier heights between stable states quantifies the global stability of the gene regulatory system. The kinetic paths based on the minimum action principles quantify the transition processes between different cell states. I will also discuss some applications of this approach in the biological systems, including cancer, cell cycle, and epithelial-mesenchymal transitions (EMT).
Dr. Chunhe Li is an Associate Professor in Shanghai Center for Mathematical Sciences at Fudan University. He is also a faculty affiliate in the Institute of Science and Technology for Brain-Inspired Intelligence at Fudan University. Dr. Li received his B.S. from Tianjin University in 2002, and Ph.D. in Analytical chemistry from Chinese Academy of Sciences in 2011. Prior to joining Fudan University in 2016, he was a postdoctoral fellow at Stony Brook University and University of California at Irvine. Dr. Li’s research focuses on computational biophysics, systems biology, stochastic dynamics of gene regulatory networks, modelling of cancer and stem cell networks and data mining. In particular, he is interested in understanding the underlying mechanisms of cell fate decisions in development and cancer. Dr. Li has been elected to Thousand Youth Talents Program in China.