Xiongfei Fu, Chinese Academy of Sciences
Room 306, No. 5, Science Building
Chemotactic bacteria migrates as a group by consuming chemoattractant collectively. Recent study showed this collective migration can coordinate individuals of different abilities to form spatially ordered structures in the traveling band. By analyzing single cell trajectories during group migration, we showed that not only the allocation of cells is self-organized, but also bacteria behavior is spatially structured. Cells at the back are better polarized towards the migration direction of the group. The polarity difference imposes dynamic flows on individual cells. The bacterial flows cycle around different centers for individuals of different chemotactic abilities, resulting a stable self-organized structure during migration. Our results revealed how individual bacterial behaves to form collective motion.
Dr. Fu received his B. Sc. degree in Physics from Zhejiang University. He obtained a PhD in physics from the University of Hong Kong, where he start to work in the modeling of synthetic genetic circuits and quantitative characterize the synthetic bio-systems that couples cell density and motility to form periodic stripe patterns. Then, he undertook postdoctoral training at the Department of Molecular, Cellular, and Developmental Biology, Yale University, where he studied the mechanism to balance between phenotypic diversity and coordinated group behavior . In 2016, he started his lab in Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, CAS, focusing on the application of quantitative analytics and advanced instrumentation from physics and engineering to biological study, to facilitate our design ability of living system.