Hu Dan, professor of mathematics, Chang Jiang Scholars award (Young scholars); bachelor and doctorate of Peking University, and post-doctorate of Courant Institute of New York University; he has extensive interest in the modeling, simulation and analysis of physical and biological systems, and his study focuses on adaptation of biological transport networks, blood flow and blood pulse waves, and rare event dynamics in life science. His group built mathematical models to describe the adaptation and initiation process of biological transport networks. The models were successfully used in prediction of vessel pruning in embryo zebra fish. His group developed analysis method and fast numerical algorithm for propagation of blood pulse waves, based on which they are able to explain the correlations between features in blood pressure waveforms and vascular diseases. They also developed analysis method for free energy calculation of complex rare event dynamics and applied it in study of transmembrane permeation of ions and interaction of antimicrobial peptides and lipid membranes. His work was published in Physical Review Letters, PLoS Biology, and Nature Communications, et al. In particular, the work on vessel pruning in embryo zebra fish has been highlighted by Nature.
Adaptation and initiation of blood vessel systems and general biological transport networks.
Modeling and simulation of blood flow and blood pulse; the relation between arterial tree structure and pulse phase.
Molecular dynamics simulations and free energy calculation in peptide-membrane dynamics; the function of antimicrobial peptides.
T. Du, D. Hu*, and D. Cai, “Outflow Boundary Conditions for Blood Flow in Arterial Trees”, PLoS One, 10 (5): e0128597. doi:10.1371/journal.pone.0128597 (2015).
Y. Wang, D. Hu, and D. Wei, “Transmembrane Permeation Mechanism of Charged Methyl Guanidine”, J. Chem. Theory Comput., DOI: 10.1021/ct400738r, (2014).
D. Hu, and D. Cai, “Adaptation and Optimization of Biological Transport Networks”, Phys. Rev. Lett., 111, 138701 (2013) (Cover article).
Q. Chen, L. Jiang, C. Li, D. Hu, J. Bu, D. Cai, and J. Du, “Haemodynamics-Driven Develop-mental Pruning of Brain Vasculature in Zebrafish”, PLoS Biol 10(8):e1001374 (2012) (Featured and cover article, highlighted by Synopsis of PLoS Biology 2012, e1001375; Nature 2012, 488:560; and Faculty of 1000, Must-read).
D. Hu, P. Zhang, and W. E, “Continuum Theory of a Moving Membrane”, Phys. Rev. E, 75, 041605 (2007).