Framework Nucleic Acids


Fan Chunhai, laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences; School of Chemistry and Chemical Engineering, SJTU


2018.09.26 16:00-17:30


Upper Hall 115


Proteins and nucleic acids are dynamically organized in cells to realize their physiological functions with spatial and temporal orderliness. This type of elegant supermolecular assembly has inspired researchers to create molecular/biomolecular structures with dynamic organization outside of the cells. In particular, DNA nanotechnology has proven to possess extraordinary flexibility and convenience for “bottom-up” construction of exquisite nanostructures with high controllability and precision, which holds great promise in a wide range of applications, e.g., nanofabrication and molecular electronics, in-vivo and in-vitro sensing and drug delivery. In this talk, I will present several examples of using framework nucleic acids (FNAs) for dynamic organization of biomolecules in vitro and in vivo. FNAs are DNA architecture with high structural stability and designable mechanical rigidity, which are suitable for organization of higher-ordered nanocomplexes and nanodevices. As examples, we employed FNAs to engineer the biosensing interface and cytoplasmic interface for molecular diagnosis and imaging.


Chunhai Fan is a chair professor at SJTU. He is a fellow of Royal Society of Chemistry (FRSC), an elected fellow of the International Society of Electrochemistry (ISE) and American Association for the Advancement of Science (AAAS). He is also an Associate Editor of ACS Applied Materials & Interfaces. Dr. Fan has published ~300 papers in peer-reviewed journals, and was recognized as High Cited Researchers. His work has been recognized by many awards including National Natural Science Prize (2016), National Award for Young Scientists of China (2011).