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Neural Structural Networks - from C.Elegans Neuronal Network to Human Brain Network

Speaker

Yuhan Chen, Beijing Normal University

Time

2019.06.20 15:00-16:00

Venue

Room 306, No. 5, Science Building

Abstract

The neural structural networks support multiple functions across different species. In this talk, we explore organization and formation principles of neural structural networks and their relationship with functional maintenance and metabolism based on our previous six studies. From the simplest nervous system C. elegans neuronal network, we applied information flow analysis reveals multiplexed functional circuits. The scaling law for various features in the gray matter and white matter across over 100 mammal species releases the scaling law for neural structural networks. Balance of multiple constraints shape the formation of neural structural networks. Association of metabolism and structural connectome reveals benefit-risk balance on the human brain. Deposition of amyloid-β in Alzheimer’s disease was developed based on the model on the human structural network. The large-scale structural weighted network on the macaque brain is acquired by predicting missing links based on cytoarchitecture, topology and spatial proximity of brain regions.