创新药物设计与发现
Speaker

张健
上海交通大学医学院

Time
2022-05-26 15:30 ~ 16:30
Venue
Online
Tencent
  • https://meeting.tencent.com/dm/LJKJyHrb2ZnX
  • Conference ID: 666587839
  • Password: 187521
    • Bio
    张健教授，上海交通大学医学院药物化学与生物信息学中心主任，兼任宁夏医科大学药学院院长，国务院学位委员会学科评议组成员，国家杰出青年基金、国家万人计划、长江学者奖励计划青年学者获得者。主要从事药物设计、药物化学和化学生物学研究，特别是精准靶标识别和First-in-class原创药物先导发现等方向做出了一系列突破性成果。以通讯作者在包括Nat Chem Biol, Nat Commun, Sci Adv等国际学术杂志上发表SCI论文100余篇。累积引用超过9000次，H因子为51，第一发明人申请国内外专利16项 (已转让6项)。受邀以通讯作者在国际顶尖综述杂志Chem Rev, Chem Soc Rev, Acc Chem Res撰写变构药物机制与发现综述；受Springer-Nature出版社邀请作为主编撰写国际首本变构药物发现专著Protein Allostery in Drug Discovery；常年任Science、Nat Chem等100余种SCI期刊审稿人，RSC Med Chem等10余种SCI期刊编委，瑞士NSF、澳大利亚FWF、新加坡IAF-PP等基金和西班牙University of Barcelona等学校Tenure考核的国际评审人。先后获美国化学会Excellent Research Advisor、中国药学会生物医药创新奖、2017年中国十大科技新锐人物等荣誉，担任国家自然科学基金委人才项目会评专家、国家卫健委卫生健康高级人才评价专家、中国化学会、中国药学会、中国医师协会精准医学委员会等专委会委员。
    近5年代表性文章
    1. Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Xu Y*, Chen G*, Zhang J*. Identification of a cellular active SIRT6 allosteric activator. Nat Chem Biol. 2018, 14(12): 1118-1126.
    2. Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G, Yu J*, Zhang J*. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat Chem Biol. 2017, 13(9):994-1001.
    3. Lu S*, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun J*, Zhang J*. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as novel targets for allosteric drug design. Nat Commun. 2021, 12(1): 4721.
    4. Ni D, Wei J, He X, Rehman AU, Li X, Qiu Y, Pu J, Lu S*, Zhang J*. Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy. Chem Sci. 2020, 12: 464-476.
    5. Lu S, Shen Q, Zhang J*. Allosteric methods and their applications: facilitating the discovery of allosteric drugs and the investigation of allosteric mechanisms. Acc Chem Res. 2019, 52(2): 492-500.
    6. Shen Q, Cheng F, Song H, Lu W, Zhao J, An X, Liu M, Chen G, Zhao Z*, Zhang J*. Proteome-scale investigation of protein allosteric regulation perturbed by somatic mutations in 7,000 cancer genomes. Am J Hum Genet. 2017, 100(1): 5-20.
    7. Lu S*, Ni D, Wang C, He X, Lin H, Wang Z*, Zhang J*. Deactivation pathway of Ras GTPase underlies conformational substates as targets for drug design. ACS Catalysis. 2019, 9(8): 7188-7196.
    8. Huang M, Song K, Liu X, Lu S, Shen Q, Wang R, Gao J, Hong Y, Li Q, Ni D, Xu J, Chen G, Zhang J*. AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses. Nucleic Acids Res. 2018, 46: 451-458.
    9. Liu X, Lu S, Song K, Shen Q, Ni D, Li Q, He X, Zhang H, Wang Q, Chen Y, Li X, Wu J, Sheng C, Chen G, Lu X*, Zhang J*. Unraveling allosteric landscapes of allosterome with ASD. Nucleic Acids Res. 2020, 48: 394-D401.
    10. Song K, Li Q, Gao W, Lu S, Shen Q, Liu X, Wu Y, Wang B, Lin H, Chen G, Zhang J*. AlloDriver: a method for the identification and analysis of cancer driver targets. Nucleic Acids Res. 2019, 47: 315-321.